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Association Between the Amount of Vaginal Mesh Used With Mesh Erosions and Repeated Surgery After Repairing Pelvic Organ Prolapse and Stress Urinary Incontinence

Journal Article

Importance: Mesh, a synthetic graft, has been used in pelvic organ prolapse (POP) repair and stress urinary incontinence (SUI) to augment and strengthen weakened tissue. Polypropylene mesh has come under scrutiny by the US Food and Drug Administration...

Prescribing of Clozapine and Antipsychotic Polypharmacy for Schizophrenia in a Large Medicaid Program

Journal Article

OBJECTIVE: Underuse of clozapine and overuse of antipsychotic polypharmacy are both indicators of poor quality of care. This study examined variation in prescribing clozapine and antipsychotic polypharmacy across providers, as well as factors associated...

Registry-Based Prospective, Active Surveillance of Medical-Device Safety

Journal Article

BACKGROUND: The process of assuring the safety of medical devices is constrained by reliance on voluntary reporting of adverse events. We evaluated a strategy of prospective, active surveillance of a national clinical registry to monitor the safety of an...

Hospitals' Role In Readmissions

Journal Article

Nursing Home Use After Implantable Cardioverter-Defibrillator Implantation in Older Adults: Results from the National Cardiovascular Data Registry

Journal Article

OBJECTIVES: To evaluate the incidence and characteristics of nursing home (NH) use after implantable cardioverter-defibrillator (ICD) implantation.DESIGN: Cohort study.SETTING: Medicare beneficiaries in the National Cardiovascular Data Registry-ICD...

Regulator Loss Functions and Hierarchical Modeling for Safety Decision Making

Journal Article

BACKGROUND: Regulators must act to protect the public when evidence indicates safety problems with medical devices. This requires complex tradeoffs among risks and benefits, which conventional safety surveillance methods do not incorporate.OBJECTIVE: To...

Patterns of Antipsychotic Prescribing by Physicians to Young Children

Journal Article

OBJECTIVE: Antipsychotic use among young children has grown rapidly despite a lack of approval by the U.S. Food and Drug Administration (FDA) for broad use in this age group. Characteristics of physicians who prescribed antipsychotics to young children...

Life Expectancy after Myocardial Infarction, According to Hospital Performance

Journal Article

Background Thirty-day risk-standardized mortality rates after acute myocardial infarction are commonly used to evaluate and compare hospital performance. However, it is not known whether differences among hospitals in the early survival of patients with...

Hospital Phenotypes in the Management of Patients Admitted for Acute Myocardial Infarction

Journal Article

OBJECTIVES: To characterize hospital phenotypes by their combined utilization pattern of percutaneous coronary interventions (PCI), coronary artery bypass grafting (CABG) procedures, and intensive care unit (ICU) admissions for patients hospitalized for...

Handling incomplete correlated continuous and binary outcomes in meta-analysis of individual participant data

Journal Article

Meta-analysis of individual participant data (IPD) is increasingly utilised to improve the estimation of treatment effects, particularly among different participant subgroups. An important concern in IPD meta-analysis relates to partially or completely...

Accounting For Patients' Socioeconomic Status Does Not Change Hospital Readmission Rates

Journal Article

There is an active public debate about whether patients' socioeconomic status should be included in the readmission measures used to determine penalties in Medicare's Hospital Readmissions Reduction Program (HRRP). Using the current Centers for Medicare...

Geographic and Temporal Variation in Cardiac Implanted Electric Devices to Treat Heart Failure

Journal Article

BACKGROUND: Cardiac implantable electric devices are commonly used to treat heart failure. Little is known about temporal and geographic variation in use of cardiac resynchronization therapy (CRT) devices in usual care settings.METHODS AND RESULTS: We...